What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in PAI-1, study by study
4 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| diet | Ad libitum diet enriched with Iberian cured ham (acorn- or mixed-fed) for 6 weeks in healthy adults aged 25-55 | PAI-1 change -6.2 +/- 17.7 ng/mL with cured ham vs +0.3 +/- 1.4 ng/mL control after 6 weeks (P=0.020), persisting 6 weeks after stopping | RCT | Saban-Ruiz J, et al. The journal of nutrition, health & aging. 2017. Iberian… |
| pharmacologic | Statin therapy of any type and dose vs control (16 RCTs, 19 treatment arms) | Lowers plasma PAI-1 concentration by 15.72 ng/mL (95% CI -25.01 to -6.43) | meta-analysis | Sahebkar A, et al. Thrombosis and haemostasis. 2016. Impact of statin therapy… |
| pharmacologic | Fibrate therapy (gemfibrozil 6 trials, bezafibrate 4, fenofibrate 5) vs control | No significant change in plasma PAI-1 concentration: -11.39 ng/mL (95% CI -26.64 to 3.85) | meta-analysis | Sahebkar A, et al. Atherosclerosis. 2015. Impact of fibrate therapy on plasma… |
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ Major depressive disorder · patients with MDD vs healthy controls | SMD +0.27 (95% CI 0.01 to 0.53) | MDD patients vs healthy controls · 507 patients with major depressive disorder and 3453 controls (6 studies) | meta analysis · PMID 34798692 |
| ↑ Non-alcoholic fatty liver disease · patients with NAFLD vs controls | +17.15 ng/mL (95% CI 7.72 to 26.57) | NAFLD patients vs non-NAFLD controls · Adults with NAFLD (imaging- or biopsy-diagnosed) and controls (11 of 33 studies pooled) | meta analysis · PMID 35574617 |
Sources
- See the catalogue entry in the research dashboard.
Related markers: Angiopoietin-2 · Coagulation Factor VIII · Coagulation Factor VIIc · D-dimer · Plasma Viscosity · Soluble ICAM-1 (sICAM-1) · von Willebrand Factor (vWF)