Biomarkers · Coagulation
Coagulation Factor VIIc
Lower values go with lower risk of death. Not measured in our NHANES panel. The curve is drawn from the published study (source below).
Coagulation Factor VIIc and risk of death
Published curve higher than the NHANES fitNHANES fit higher
Risk of death relative to the curve's reference value, drawn from the published study (source below).
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in Coagulation Factor VIIc, study by study
5 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| diet | Controlled feeding of a diet with 26% of energy from fat and 5% from saturated fat for 8 weeks, versus an average American diet (37% fat, 16% SFA), in healthy adults (DELTA Study 1) | Mean factor VIIc 2.6% lower on the Low-Sat diet (1.8% lower on the Step 1 diet, 9% SFA) than on the average American diet after 8 weeks; fibrinogen rose 2.8% | RCT | Kris-Etherton PM, Stewart PW, Ginsberg HN, et al. The Type and Amount of… |
| diet | Intensive behavioural programme to cut total fat to 20% of calories and raise vegetable/fruit and grain intake in postmenopausal women (Women's Health Initiative Dietary Modification Trial) | Factor VIIc 4.29% lower in the low-fat intervention group than comparison group by year 6; LDL-C -3.55 mg/dL, DBP -0.31 mmHg | RCT | Howard BV, Van Horn L, Hsia J, et al. Low-fat dietary pattern and risk of… |
Things that worsen it
| Type | Condition or exposure | Reported effect | Evidence | Source |
|---|---|---|---|---|
| diet | Thirty days on a high-fat diet in healthy young men, compared with their own baseline | Factor VIIc rises 9% (fibrinogen +22%, factor VIIIc +4%) after 30 days of a high-fat diet; Mediterranean diet was associated with lower factor VIIc (P=0.034) and red wine supplementation lowered factor VIIc (P=0.05) | RCT | Mezzano D, Leighton F, Martinez C, et al. Complementary effects of… |
| diet | Four weeks on an isocaloric high-saturated-fat diet (about 62% of energy from fat) compared with a low-fat diet (<20% energy from fat) in healthy adults | Factor VIIc 13.1% of standard higher on the high-saturated-fat diet and 6.5% of standard higher on the high-unsaturated-fat diet than on the low-fat diet | RCT | Mitropoulos KA, Miller GJ, Martin JC, et al. Dietary fat induces changes in… |
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ Carotid artery stenosis (moderate-to-severe) · subjects with >=16% right internal carotid lumen reduction vs no stenosis | +6 IU/dL (95% CI -1 to 12) | moderate-to-severe carotid artery disease vs no stenosis · 954 participants aged >=55 y, Rotterdam Elderly Study (42 with carotid disease) | cross sectional · PMID 1592472 |
Environmental and occupational exposures
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ Ambient ozone (prior-year exposure) · per 10 ppb ozone, prior-year average | +5.7 % per 10 ppb ozone, prior-year average (95% CI 2.9 to 8.5) | percent increase in factor VIIc per 10 ppb prior-year ozone · 2086 midlife women, Study of Women's Health Across the Nation (SWAN), 1999-2004 | prospective cohort · PMID 26600256 |
Sources
- Risk curve: Anderson 2014 (PMID 25014036): all-cause HR 1.07 (1.02-1.12) per 10-unit increase in FVIIc (% activity). Scaled to published population values.
- Anderson et al. Haemostatic factors, lipoproteins and long-term mortality in a multi-ethnic population of Gujarati, African-Caribbean and European origin. Atherosclerosis. 2014;236:62-72.
Map Coagulation Factor VIIc against another biomarker.
Related markers: Angiopoietin-2 · Coagulation Factor VIII · D-dimer · Plasma Viscosity · Plasminogen Activator Inhibitor-1 (PAI-1) · Soluble ICAM-1 (sICAM-1) · von Willebrand Factor (vWF)