What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in D-dimer, study by study
1 effect with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| clinical | One night of continuous positive airway pressure treating obstructive sleep apnoea in adults with Marfan syndrome | Morning D-dimer fell from 1,108 to 882 ng/mL after a night on CPAP vs an untreated night (P = 0.023) | RCT | Sowho M, Schneider H, Jun J, et al. D-dimer in Marfan syndrome: effect of… |
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ COVID-19, death · admission D-dimer in patients who died vs survivors | +6.13 ug/mL (95% CI 4.16 to 8.11) | died vs survived, COVID-19 · COVID-19 patients, 18 studies | meta analysis · PMID 33017364 |
| ↑ COVID-19, severe disease · admission D-dimer in severe vs non-severe COVID-19 | +0.54 ug/mL (95% CI 0.28 to 0.8) | severe vs non-severe COVID-19 · COVID-19 patients, 18 studies | meta analysis · PMID 33017364 |
| ↑ Preeclampsia · preeclamptic vs normotensive pregnant women | SMD +0.81 (95% CI 0.43 to 1.18) | preeclampsia vs normotensive pregnancy · 2938 preeclampsia vs 2908 normotensive pregnant women, 31 articles | meta analysis · PMID 40770745 |
Genetic predisposition
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↕ F3 (tissue factor) rs12029080 · per-allele difference in natural-log-transformed plasma D-dimer | +0.099 ln(D-dimer) units per allele per allele | additive model, per allele · European-ancestry adults, 13 cohorts (CHARGE) | gwas · PMID 21502573 |
| ↕ F3, F5 and FGG/FGA loci combined · total variance in ln(D-dimer) explained by the three genome-wide significant loci | +1.8% | variance explained · European-ancestry adults, 13 cohorts (CHARGE) | gwas · PMID 21502573 |
Sources
- See the catalogue entry in the research dashboard.
Related markers: Angiopoietin-2 · Coagulation Factor VIII · Coagulation Factor VIIc · Plasma Viscosity · Plasminogen Activator Inhibitor-1 (PAI-1) · Soluble ICAM-1 (sICAM-1) · von Willebrand Factor (vWF)