Biomarkers · Bone & Mineral
Osteocalcin
Both low and high values go with higher risk of death. Not measured in our NHANES panel. The curve is drawn from the published study (source below).
Osteocalcin and risk of death
Published curve higher than the NHANES fitNHANES fit higher
Risk of death relative to the curve's reference value, drawn from the published study (source below).
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in Osteocalcin, study by study
4 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| pharmacologic | Bazedoxifene 20 mg daily for 12 months in postmenopausal Latin American women with osteoporosis | Serum osteocalcin -43.0% at 12 months (placebo -27.0%) | RCT | Bueno JAH, Arias L, Yu CR, et al. Menopause. 2017. |
Things that worsen it
| Type | Condition or exposure | Reported effect | Evidence | Source |
|---|---|---|---|---|
| exercise | High-intensity interval training 3 times per week for 8 weeks in people with multiple sclerosis | Osteocalcin rose from 20.88 to 23.66 ug/L (ng/mL) after 8 weeks of HIIT | RCT | Amato A, Proia P, Alioto A, et al. Sci Rep. 2024. |
| pharmacologic | Oral teriparatide (PTH 1-34) 2.5 mg tablets daily in postmenopausal women with osteoporosis | Osteocalcin +30% at 1 month, returning to baseline by 6 months | RCT | Tripto-Shkolnik L, Szalat A, Tsvetov G, et al. J Bone Miner Res. 2024. |
Sources
- Risk curve: Yeap BB 2012 (PMID 21359669): all-cause HR 1.53 (1.18-1.98) Q5 vs Q2 total osteocalcin (Q2 lowest-risk reference; Q1 vs Q2 HR 1.36, 1.02-1.80). Scaled to published population values.
- Yeap BB, Chubb SA, Flicker L, McCaul KA, Ebeling PR, Hankey GJ, Beilby JP, Norman PE. Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men Study. Osteoporos Int. 2012;23(2):599-607.
Map Osteocalcin against another biomarker.
Related markers: Bone Mineral Density T-score (DXA) · Broadband Ultrasound Attenuation (Heel) · C-Terminal Telopeptide of Type I Collagen (CTX) · Osteoprotegerin (OPG) · Parathyroid Hormone (PTH)