Biomarkers · Bone & Mineral
C-Terminal Telopeptide of Type I Collagen (CTX)
Lower values go with lower risk of death. Not measured in our NHANES panel. The curve is drawn from the published study (source below).
CTX and risk of death
Published curve higher than the NHANES fitNHANES fit higher
Risk of death relative to the curve's reference value, drawn from the published study (source below).
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in CTX, study by study
1 effect with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| pharmacologic | Oral PTH(1-34) 2.5 mg tablet once daily for 6 months in postmenopausal women with low BMD or osteoporosis | Serum CTX -16% at 3 months and -21% at 6 months below baseline with 2.5 mg dose | RCT | Tripto-Shkolnik L, Szalat A, Tsvetov G, et al. J Bone Miner Res. 2024. |
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↓ Polycystic ovary syndrome · Diagnosed or probable PCOS vs no PCOS; serum CTX-1 at midlife (17-year follow-up visit) | -13.7% (95% CI -23.7 to -2.5) | PCOS vs no PCOS, age-adjusted percent difference · Parous women in Project Viva, mean age 51 (67 PCOS, 342 no PCOS) | prospective cohort · PMID 40934620 |
Sources
- Risk curve: Robertson 2022 (PMID 35689459): all-cause HR 1.13 (1.08-1.19) per 1 standard deviation increase in serum CTX. Scaled to published population values.
- Robertson et al. Bone Turnover Markers Including Undercarboxylated Osteocalcin Are Associated With Mortality Risk in Older Men. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2022;37:1464-1472.
Map C-Terminal Telopeptide of Type I Collagen (CTX) against another biomarker.
Related markers: Bone Mineral Density T-score (DXA) · Broadband Ultrasound Attenuation (Heel) · Osteocalcin · Osteoprotegerin (OPG) · Parathyroid Hormone (PTH)