Biomarkers · Renal & Purine
Neutrophil Gelatinase-Associated Lipocalin (NGAL)
Lower values go with lower risk of death. Not measured in our NHANES panel. The curve is drawn from the published study (source below).
NGAL and risk of death
Published curve higher than the NHANES fitNHANES fit higher
Risk of death relative to the curve's reference value, drawn from the published study (source below).
NGAL by age and sex
The percentiles as a table
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| All | all | – | – | 99.3 | – | – | 4,660 | PREVEND (Groningen, NL… |
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in NGAL, study by study
1 effect with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| clinical | Dexmedetomidine 1 ug/kg loading over 10 min then 0.5 ug/kg/h until 30 min before peritoneal closure during elective laparoscopic colorectal cancer surgery | Serum NGAL 107.5 vs 179.5 ng/mL on postoperative day 1 and 70.3 vs 135.2 ng/mL on day 5 (P<0.001) | RCT | Sun W, et al. The Journal of surgical research. 2021. Effects of… |
| pharmacologic | rhC1INH 50 IU/kg intravenously before and 4 h after elective coronary angiography in patients with chronic kidney disease | Median peak change in urinary NGAL within 48 h 4.7 ng/mL vs 22.5 ng/mL with placebo (per-protocol, P=0.038) | RCT | Panagiotou A, et al. JACC. Cardiovascular interventions. 2020. A Randomized… |
Things that worsen it
| Type | Condition or exposure | Reported effect | Evidence | Source |
|---|---|---|---|---|
| pharmacologic | Empagliflozin 10 mg once daily vs placebo in adults with chronic kidney disease at risk of progression (EMPA-KIDNEY) | Urinary NGAL (indexed to creatinine) 7% higher (95% CI 0-13%) with empagliflozin, averaged over 2-18 months | RCT | Malijan GB, et al. American journal of kidney diseases : the official journal… |
Sources
- Risk curve: Daniels LB 2012 (PMID 22421304): all-cause HR 1.19 (1.07-1.32) per SD log increase in plasma NGAL. Scaled to US values (NHANES).
- Daniels LB, Barrett-Connor E, Clopton P, Laughlin GA, Ix JH, Maisel AS. Plasma neutrophil gelatinase-associated lipocalin is independently associated with cardiovascular disease and mortality in community-dwelling older adults: The Rancho Bernardo Study. J Am Coll Cardiol. 2012;59(12):1101-1109.
Map Neutrophil Gelatinase-Associated Lipocalin (NGAL) against another biomarker.
Related markers: Alpha-1-Microglobulin · Beta-2 Microglobulin · Beta-Trace Protein (BTP) · Blood Urea Nitrogen (BUN) · Estimated Glomerular Filtration Rate (eGFR) · Kidney Injury Molecule-1 (KIM-1) · Renal Artery Calcification · Serum Creatinine