Biomarkers · Renal & Purine
Beta-2 Microglobulin
Lower values go with lower risk of death. Not measured in our NHANES panel. The curve is drawn from the published study (source below).
Beta-2 Microglobulin and risk of death
Published curve higher than the NHANES fitNHANES fit higher
Risk of death relative to the curve's reference value, drawn from the published study (source below).
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in Beta-2 Microglobulin, study by study
1 effect with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| clinical | Long-term haemodialysis with high-flux rather than low-flux membranes in people with end-stage kidney disease (Cochrane review) | Predialysis beta-2 microglobulin 12.17 mg/L lower (95% CI -15.83 to -8.51) with high-flux vs low-flux membranes | meta-analysis | Palmer SC, et al. The Cochrane database of systematic reviews. 2012. High-flux… |
Sources
- Risk curve: Fang H 2023 (PMID 36930114): all-cause HR 2.5 (1.9-3.28) highest vs lowest quartile of B2M. Scaled to US values (NHANES).
- Fang H, Zhang Q, Jin L. Association of beta-2-microglobulin with cardiovascular and all-cause mortality in the general and non-CKD population. Medicine (Baltimore). 2023;102(11):e33202.
Map Beta-2 Microglobulin against another biomarker.
Related markers: Alpha-1-Microglobulin · Beta-Trace Protein (BTP) · Blood Urea Nitrogen (BUN) · Estimated Glomerular Filtration Rate (eGFR) · Kidney Injury Molecule-1 (KIM-1) · Neutrophil Gelatinase-Associated Lipocalin (NGAL) · Renal Artery Calcification · Serum Creatinine