Biomarkers · Renal & Purine
Beta-Trace Protein (BTP)
Lower values go with lower risk of death. No risk curve catalogued yet.
Published risk of death2.14×highest subquintile (Q5c, top tertile of highest quintile) vs middle quintile of BTP (95% CI 1.56–2.94) · NHANES III (1988-1994) US adults aged >=20 y, mortality linkage through Dec 31, 2006
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Genetic predisposition
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ PTGDS locus rs57024841 (African ancestry) · per copy of the A allele upstream of PTGDS | +6 % higher plasma BTP per A allele per allele | A allele carriers vs non-carriers, additive model · African-American adults, ARIC study (replication) | gwas · PMID 23328707 |
| ↑ PTGDS locus rs57024841 (European ancestry) · per copy of the A allele upstream of PTGDS | +5 % higher plasma BTP per A allele per allele | per copy of the rs57024841 A allele (additive model) · European-American adults, ARIC study | gwas · PMID 23328707 |