PFLPhysiological Fitness Landscape

Biomarkers · Hematology

Transferrin Saturation

Lower values go with lower risk of death. Not measured in our NHANES panel. The curve is drawn from the published study (source below).

Transferrin Saturation and risk of death

Published curve higher than the NHANES fitNHANES fit higher

Risk of death relative to the curve's reference value, drawn from the published study (source below).

Published risk of death1.60×serum transferrin saturation more than 55% vs below this cutoff (95% CI 1.17–2.21) · NHANES I (1971-1974) merged with NHANES I Epidemiologic Followup Study (1992), US adults aged 25-74 (N=10,714)

Transferrin Saturation by age and sex

Each bar runs from the 5th to the 95th percentile, the darker part from the 25th to the 75th, and the tick is the median. Not a reference range or a target.

The percentiles as a table
Each row is one sex and age band: the values below which 5%, 25%, 50%, 75% and 95% of people fall (%), from the survey named in the row. Not a reference range or a target.
SexAge5th25thMedian75th95thnCycle / source
All20-3910.018.025.034.048.01,425NHANES 2017-2018
All40-5911.020.027.035.048.01,546NHANES 2017-2018
All60+13.021.027.033.046.01,890NHANES 2017-2018
Allall11.020.026.034.048.04,861NHANES 2017-2018
Men20-3915.023.029.037.051.5675NHANES 2017-2018
Men40-5916.023.029.038.049.0720NHANES 2017-2018
Men60+12.023.028.035.050.0959NHANES 2017-2018
Menall15.023.029.037.051.02,354NHANES 2017-2018
Women20-397.0015.022.030.046.0750NHANES 2017-2018
Women40-598.0017.024.432.047.0826NHANES 2017-2018
Women60+13.020.026.031.041.1931NHANES 2017-2018
Womenall9.0017.024.031.046.02,507NHANES 2017-2018

What studies found when this marker was changed

They describe what happened in those study groups, not a recommendation. See all catalogued interventions.

Measured changes in Transferrin Saturation, study by study

2 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.

Each row is one study: what was changed, the effect it reported on this marker, and the source.
TypeInterventionReported effectEvidenceSource
pharmacologicIntravenous iron supplementation compared with oral iron in adults and children with CKD and anaemia (27 studies, 3089 participants)Transferrin saturation 7.69 percentage points higher (95% CI 5.10-10.28) with IV than oral iron; ferritin +224.84 ug/L, haemoglobin +0.72 g/dLmeta-analysisO'Lone EL, et al. The Cochrane database of systematic reviews. 2019. Parenteral…
pharmacologicOral roxadustat three times weekly for 26 weeks vs epoetin alfa in Chinese patients on dialysis with anaemia, parenteral iron withheldAttenuates the decline in transferrin saturation: 4.2 percentage points higher than epoetin alfa (95% CI 1.5-6.9) at 26 weeks; hepcidin -30.2 ng/mLRCTChen N, et al. The New England journal of medicine. 2019. Roxadustat Treatment…

Sources

Map Transferrin Saturation against another biomarker.

Related markers: Absolute Lymphocyte Count · Absolute Neutrophil Count · Basophil Count · Eosinophil Count · Hematocrit · Hemoglobin Concentration · Immature Reticulocyte Fraction · Lymphocyte Percentage

Map Transferrin Saturation against another marker