Biomarkers · Hematology

Lymphocyte Percentage

Higher values go with lower risk of death. In NHANES 1999–2018 with linked mortality to 2019, each standard deviation above average goes with 18% lower risk of death. We found the same pattern in NHANES

Lymphocyte Percentage and risk of death

NHANES, our fit with 95% CIPublished curve

Published curve higher than the NHANES fitNHANES fit higher

Risk of death relative to each curve's own reference value, so the two curves need not cross 1 at the same point. The dotted vertical line marks the NHANES median.

Risk of death per SD (NHANES)0.82×95% CI 0.80–0.84 · 48,955 adults, 7,151 deaths

Published risk of death1.73×relative lymphocyte count <= 20% vs > 20% (95% CI 1.21–2.48) · CHF Italian Study: 423 hospitalized patients >65 y with congestive heart failure (mean age 76), 3-year follow-up

Value of the measurement+0.029gain in concordance within age bands; rank 9 of 56 · all tests

Lymphocyte Percentage by age and sex

Each bar runs from the 5th to the 95th percentile, the darker part from the 25th to the 75th, and the tick is the median. Not a reference range or a target.

The percentiles as a table

Each row is one sex and age band: the values below which 5%, 25%, 50%, 75% and 95% of people fall (%), from the survey named in the row. Not a reference range or a target.
Sex	Age	5th	25th	Median	75th	95th	n	Cycle / source
All	20-39	19.7	26.6	31.7	37.3	46.9	1,456	NHANES 2017-2018
All	40-59	18.8	25.0	31.1	36.1	44.4	1,582	NHANES 2017-2018
All	60+	16.5	22.4	27.9	34.4	42.8	1,939	NHANES 2017-2018
All	all	17.9	24.8	30.5	35.9	44.7	4,977	NHANES 2017-2018
Men	20-39	19.1	27.0	32.3	38.4	47.4	698	NHANES 2017-2018
Men	40-59	17.9	24.7	30.7	35.4	43.3	740	NHANES 2017-2018
Men	60+	15.8	21.5	26.9	33.9	42.6	981	NHANES 2017-2018
Men	all	17.5	24.5	30.4	35.9	44.4	2,419	NHANES 2017-2018
Women	20-39	19.8	26.4	30.9	36.3	45.5	758	NHANES 2017-2018
Women	40-59	19.6	25.9	31.5	36.8	46.5	842	NHANES 2017-2018
Women	60+	16.7	23.2	28.6	34.8	42.8	958	NHANES 2017-2018
Women	all	18.6	25.2	30.5	35.9	44.9	2,558	NHANES 2017-2018

Sources

Risk curve: Acanfora 2001 (PMID 11431674): all-cause HR 1.73 (1.21-2.48) relative lymphocyte count <= 20% vs > 20%. Scaled to US values (NHANES).
Acanfora et al. Relative lymphocyte count: a prognostic indicator of mortality in elderly patients with congestive heart failure. American heart journal. 2001;142:167-73.
NHANES curve: our Cox model adjusted for age and sex, NHANES 1999–2018 with linked mortality to 2019.

Map Lymphocyte Percentage against another biomarker.

Map Lymphocyte Percentage against another marker