Biomarkers · Oxidative Stress
Total Plasma Thiols
Higher values go with lower risk of death. Not measured in our NHANES panel. The curve is drawn from the published study (source below).
Total Plasma Thiols and risk of death
Published curve higher than the NHANES fitNHANES fit higher
Risk of death relative to the curve's reference value, drawn from the published study (source below).
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in Total Plasma Thiols, study by study
2 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| exercise | Supervised exercise training intervention (without dietary component) over 15 months in kidney transplant recipients (ACT trial) | Serum free thiols 9.0 uM (95% CI -14.4 to 32.3) vs usual care at 15 months with exercise alone (not significant; +20.2 uM at 3 months, P=0.067) | RCT | Bourgonje AR, et al. Free Radic Biol Med. 2025. Effect of lifestyle… |
| lifestyle | Combined supervised exercise training plus dietary intervention over 15 months in kidney transplant recipients (ACT trial) | Serum free thiols (R-SH) 32.8 uM (95% CI 9.4-56.2) higher than usual care at 15 months with exercise plus diet (P=0.006) | RCT | Bourgonje AR, et al. Free Radic Biol Med. 2025. Effect of lifestyle… |
Sources
- Risk curve: Schottker B 2015 (PMID 25070660): all-cause HR 0.68 (0.53-0.87) top vs bottom tertile of total thiol levels (protective form as reported). Scaled to published population values.
- Schottker B, Saum KU, Jansen EH, Boffetta P, Trichopoulou A, Holleczek B, Dieffenbach AK, Brenner H. Oxidative stress markers and all-cause mortality at older age: a population-based cohort study. J Gerontol A Biol Sci Med Sci. 2015;70(4):518-524.
Map Total Plasma Thiols against another biomarker.
Related markers: 3-Nitrotyrosine (3-NT) · 4-Hydroxynonenal (4-HNE) · 8-Hydroxy-2'-deoxyguanosine (8-OHdG) · Malondialdehyde (MDA) · Peroxiredoxin-4 (PRDX4) · Protein carbonyls · Total thiol levels · Urinary 8-oxoGuo