Biomarkers · Oxidative Stress

Urinary 8-oxoGuo

No risk curve catalogued yet.

What studies found when this marker was changed

They describe what happened in those study groups, not a recommendation. See all catalogued interventions.

Measured changes in Urinary 8-oxoGuo, study by study

3 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Study results in the groups studied, not predictions for a person.

Things that worsen it

Each row is one study: what was changed, the effect it reported on this marker, and the source.
Type	Condition or exposure	Reported effect	Evidence	Source
diet	Weight-stable carbohydrate-reduced high-protein diet (30E% carbohydrate) vs conventional diabetes diet (50E%) in type 2 diabetes, randomised crossover	24-h urinary 8-oxoGuo was 9.3% higher after 4 weeks on the carbohydrate-reduced high-protein diet than on the conventional diabetes diet (p = .03); crossover, n=30	RCT	Skytte MJ, et al. Scand J Clin Lab Invest. 2020;80(5):401-407.
pharmacologic	One week of oral clarithromycin vs placebo in healthy adults (harmful exposure: raises RNA oxidation)	24-h urinary 8-oxoGuo rose 14.9% (95% CI 3.7 to 26.1%) after 1 week of clarithromycin vs placebo in healthy adults	RCT	Larsen EL, et al. Br J Clin Pharmacol. 2017;83(8):1643-1653.
pharmacologic	Metformin 1000 mg twice daily vs placebo for 18 months, on top of insulin therapy, in type 2 diabetes	Urinary 8-oxoGuo rose 7.1% (95% CI 0.5 to 14.0%) with metformin vs placebo over 18 months; 415 randomised (number written out in the abstract)	RCT	Larsen EL, et al. Free Radic Biol Med. 2022;178:18-25.

Sources

See the catalogue entry in the research dashboard.