Biomarkers · Oxidative Stress

8-Hydroxy-2'-deoxyguanosine (8-OHdG)

No risk curve catalogued yet.

What studies found when this marker was changed

They describe what happened in those study groups, not a recommendation. See all catalogued interventions.

Measured changes in 8-OHdG, study by study

3 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Study results in the groups studied, not predictions for a person.

Each row is one study: what was changed, the effect it reported on this marker, and the source.
Type	Intervention	Reported effect	Evidence	Source
nutraceutical	Broccoli sprout extract capsules (glucoraphanin/sulforaphane precursor) taken daily for 2 months in men with fatty liver	Urinary 8-OHdG fell from median 6.66 to 5.49 ng/mg-creatinine after 2 mo; no change with placebo	RCT	Kikuchi M, Ushida Y, Shiozawa H, et al. World J Gastroenterol. 2015.
nutraceutical	Purified anthocyanin capsules 320 mg/day for 12 weeks in adults with dyslipidemia	Urinary 8-OHdG reduced 36% with 320 mg/day at 12 weeks, more than with 80 or 40 mg/day	RCT	Zhang H, Xu Z, Zhao H, et al. Redox Biol. 2020.
pharmacologic	Intravenous propionyl-L-carnitine 6 g/day for 7 days in peripheral arterial disease	Serum 8-OHdG fell from 3.62 to 2.64 ng/mL (-27%) after 7 days	RCT	Loffredo L, Marcoccia A, Pignatelli P, et al. Eur Heart J. 2007.

What else moves this marker

They describe those study groups, not an individual, and an association is not a cause.

Diseases and conditions

Each row is one study: what it compared and the change it reported in this marker.
What	Effect on the marker	Comparison · population	Source
↑ Cardiovascular disease · CVD patients vs controls (urine or blood 8-OHdG)	SMD +1.04 (95% CI 0.61 to 1.47)	CVD patients vs controls · 14 case-control studies, 810 CVD patients and 1106 controls	meta analysis · PMID 26650622
↑ Heart failure · HF patients vs controls, urinary 8-OHdG	+6.28 ng/mg creatinine (95% CI 4.01 to 8.56)	HF patients vs controls (urine) · 6 studies, 446 HF patients and 140 controls	meta analysis · PMID 28065503

Environmental and occupational exposures

Each row is one study: what it compared and the change it reported in this marker.
What	Effect on the marker	Comparison · population	Source
↑ Perceived psychosocial stress · per one-category increase in self-reported perceived stress	+2.1 percent per one-category increase in self-reported perceived stress	per one-category increase of perceived stress (urinary 8-OHdG) · General Japanese population aged 45-74, cohort follow-up survey	cross sectional · PMID 28700458

Sources

See the catalogue entry in the research dashboard.