Biomarkers · Inflammation
Pentraxin-3 (PTX3)
Lower values go with lower risk of death. No risk curve catalogued yet.
Published risk of death1.08×per 1 SD increase in PTX3 (1.89 ng/mL) (95% CI 1.02–1.15) · Cardiovascular Health Study participants (older adults) free of prevalent CVD, n=1583
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ Acute exacerbation of COPD (vs stable COPD) · Serum PTX-3, AECOPD vs stable COPD (severity-stage contrast) | SMD +0.58 (95% CI 0.41 to 0.74) | AECOPD patients vs stable COPD patients · 996 AECOPD vs 1,414 stable COPD patients | meta analysis · PMID 39151096 |
| ↑ COPD · Serum PTX-3 in COPD patients vs healthy controls | SMD +0.51 (95% CI 0.3 to 0.73) | COPD patients vs healthy controls · 17 studies; 1,414 stable COPD, 996 AECOPD and 1,016 healthy controls | meta analysis · PMID 39151096 |
| ↑ Preeclampsia · Circulating PTX3 in pregnant women with vs without PE | SMD +2.48 | Preeclampsia vs pregnancy without PE · 9 case-control studies; 396 PE patients and 438 controls | meta analysis · PMID 32590749 |
| ↑ Rheumatoid arthritis · Circulating PTX3 in RA patients vs healthy controls | SMD +0.97 (95% CI 0.48 to 1.45) | RA patients vs healthy controls · 20 articles / 21 studies of RA patients vs healthy controls | meta analysis · PMID 35708089 |
Genetic predisposition
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ PTX3 rs2305619 AA genotype vs GA/GG · Plasma PTX3 by rs2305619 genotype (Chinese Han, cryptococcosis study participants) | ratio 8.23 | AA 60.28 +/- 16.12 vs GA/GG 7.32 +/- 0.79 (units not reported); ratio of means · 97 HIV-uninfected cryptococcosis patients and 120 healthy controls, West China Hospital | case control · PMID 33320373 |