Biomarkers · Inflammation

CD8+ T-Cell Count

Both low and high values go with higher risk of death. No risk curve catalogued yet.

Published risk of death1.13×higher vs middle tertile of CD8 count (>1138 vs 761-1138 cells/uL) (95% CI 1.01–1.26) · ART-CC: 13 European and North American cohorts of HIV-positive adults virologically suppressed on ART with CD4 >=350 cells/uL

What else moves this marker

They describe those study groups, not an individual, and an association is not a cause.

Environmental and occupational exposures

Each row is one study: what it compared and the change it reported in this marker.
What	Effect on the marker	Comparison · population	Source
↓ Ambient polycyclic aromatic hydrocarbons (PAHs) · per 100 ng/m3 PAH averaged over the 14 days before birth	-1 percentage points of cord-blood CD8+ fraction per 100 ng/m3 PAH averaged over the 14 days before birth (95% CI -1.8 to -0.2)	per 100 ng/m3 higher ambient PAH (approximately 2 SD) · 1397 cord-blood samples from deliveries in two districts of the Czech Republic, 1994-1998	prospective cohort · PMID 16203253

Sources

Trickey et al. CD4:CD8 Ratio and CD8 Count as Prognostic Markers for Mortality in Human Immunodeficiency Virus-Infected Patients on Antiretroviral Therapy: The Antiretroviral Therapy Cohort Collaboration (ART-CC). Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2017;65:959-966.