Biomarkers · Inflammation
CD4:CD8 T-Cell Ratio
Higher values go with lower risk of death. No risk curve catalogued yet.
Published risk of death0.86×higher CD4/CD8 ratio (continuous; unit of contrast not reported) (95% CI 0.76–0.96) · Dementia-free Framingham Offspring participants at exam 7 (1998-2001), mean age 62 (40-88), 52% female
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in CD4:CD8 T-Cell Ratio, study by study
1 effect with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| supplement | Daily synbiotic (two L. plantarum strains, one P. acidilactici strain plus fibre-based prebiotic) for 6 months in HIV immuno-discordant patients on cART | Median CD4/CD8 ratio 0.72 -> 0.76 at 6 months (median change +0.04, IQR 0.19; p=0.03) in the synbiotic arm | RCT | Blázquez-Bondia C, Parera M, Català-Moll F, et al. Probiotic effects on… |
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ COVID-19 severity · severe vs mild COVID-19 | +0.26 ratio (95% CI -0.02 to 0.55) | severe vs mild COVID-19 cases · 21 studies, 2033 COVID-19 patients (severe vs mild) | meta analysis · PMID 34344353 |