Biomarkers · Hematology
Platelet Distribution Width
Lower values go with lower risk of death. No risk curve catalogued yet.
Published risk of death1.44×PDW (continuous, contrast not reported), all-cause mortality at 0-5 years of follow-up… (95% CI 1.21–1.72) · NHANES III US adults aged >=18 without history of myocardial infarction, linked to mortality files (follow-up range 0 to 31 years)
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in Platelet Distribution Width, study by study
1 effect with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| pharmacologic | Liraglutide added to metformin/sulfonylurea for 16 weeks in obese adults with poorly controlled type 2 diabetes | PDW falls from 15.0 to 12.8 fL (-2.2 +/- 0.7) with liraglutide vs 15.0 to 13.6 fL (-1.4 +/- 0.5) with oral agents alone; cIMT -0.30 mm | RCT | Meng XM, Hao YP, Yu S, et al. [Effect of Liraglutide on platelet distribution… |
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ Acute appendicitis · acute appendicitis vs healthy controls | SMD +0.3 (95% CI -0.22 to 0.83) | acute appendicitis vs healthy controls · 17 observational studies | meta analysis · PMID 33439467 |
| ↑ Autoimmune thyroid disease · AITD patients vs healthy controls | SMD +0.06 (95% CI -0.164 to 0.284) | AITD vs healthy controls · 3824 AITD patients and 2349 healthy controls, 19 articles | meta analysis · PMID 36618418 |
| ↑ Psoriasis · psoriasis patients vs healthy controls | SMD +0.29 (95% CI 0.03 to 0.55) | psoriasis vs healthy controls · 1749 psoriasis patients and 1538 healthy controls, 22 studies | meta analysis · PMID 34918687 |