Biomarkers · Hematology

Neutrophil Percentage

Lower values go with lower risk of death. In NHANES 1999–2018 with linked mortality to 2019, each standard deviation above average goes with 19% higher risk of death. We found the same pattern in NHANES

Neutrophil Percentage and risk of death

NHANES, our fit with 95% CIPublished curve

Published curve higher than the NHANES fitNHANES fit higher

Risk of death relative to each curve's own reference value, so the two curves need not cross 1 at the same point. The dotted vertical line marks the NHANES median.

Risk of death per SD (NHANES)1.19×95% CI 1.16–1.21 · 48,955 adults, 7,151 deaths

Published risk of death2.59×admission neutrophil percentage >= 82.1% vs < 82.1% (95% CI 1.21–5.53) · 701 consecutive STEMI patients undergoing primary PCI at nine institutions in northwest China, 2009-2011

Value of the measurement+0.024gain in concordance within age bands; rank 12 of 56 · all tests

Neutrophil Percentage by age and sex

Each bar runs from the 5th to the 95th percentile, the darker part from the 25th to the 75th, and the tick is the median. Not a reference range or a target.

The percentiles as a table

Each row is one sex and age band: the values below which 5%, 25%, 50%, 75% and 95% of people fall (%), from the survey named in the row. Not a reference range or a target.
Sex	Age	5th	25th	Median	75th	95th	n	Cycle / source
All	20-39	41.0	50.8	57.1	62.6	71.1	1,456	NHANES 2017-2018
All	40-59	42.2	51.7	57.8	64.0	71.8	1,582	NHANES 2017-2018
All	60+	43.5	52.9	59.4	65.0	73.6	1,939	NHANES 2017-2018
All	all	42.1	51.9	57.9	64.0	72.0	4,977	NHANES 2017-2018
Men	20-39	39.0	49.1	55.5	61.7	71.2	698	NHANES 2017-2018
Men	40-59	42.9	51.5	57.8	64.5	72.7	740	NHANES 2017-2018
Men	60+	43.3	52.2	59.9	65.5	75.3	981	NHANES 2017-2018
Men	all	41.7	51.0	57.3	64.0	72.4	2,419	NHANES 2017-2018
Women	20-39	42.1	52.8	58.3	63.5	71.1	758	NHANES 2017-2018
Women	40-59	41.7	52.1	57.9	63.7	71.1	842	NHANES 2017-2018
Women	60+	43.7	53.5	59.1	64.7	72.7	958	NHANES 2017-2018
Women	all	42.8	52.7	58.4	64.1	71.7	2,558	NHANES 2017-2018

What else moves this marker

They describe those study groups, not an individual, and an association is not a cause.

Diseases and conditions

Each row is one study: what it compared and the change it reported in this marker.
What	Effect on the marker	Comparison · population	Source
↑ Hand, foot and mouth disease, severe vs mild · Neutrophil ratio in severe vs mild HFMD (severity-stage contrast, children)	SMD +0.55 (95% CI 0.17 to 0.93)	Severe HFMD vs mild HFMD · 32 articles comprising 781,903 HFMD cases (mostly China); subgroup n for neutrophil ratio not given	meta analysis · PMID 35482791

Sources

Risk curve: Men 2015 (PMID 25989351): all-cause OR 2.59 (1.21-5.53) admission neutrophil percentage >= 82.1% vs < 82.1%. Scaled to US values (NHANES).
Men et al. Prognostic Value of the Percentage of Neutrophils on Admission in Patients with ST-elevated Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Archives of medical research. 2015.
NHANES curve: our Cox model adjusted for age and sex, NHANES 1999–2018 with linked mortality to 2019.

Map Neutrophil Percentage against another biomarker.

Map Neutrophil Percentage against another marker