Biomarkers · Inflammation
Monocyte Chemoattractant Protein-1 (MCP-1 / CCL2)
Both low and high values go with higher risk of death. No risk curve catalogued yet.
Published risk of death2.11×highest vs middle (reference) tertile of MCP-1 (95% CI 1.31–3.40) · CAD patients aged 40-85 years, China
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ COVID-19 severity · severe vs mild COVID-19 | SMD +3.41 (95% CI 2.42 to 4.4) | severe vs mild COVID-19 cases · 21 studies of hospitalised COVID-19 patients | meta analysis · PMID 34344353 |
| ↑ Major depression · DSM-IV major depression vs healthy controls, unstimulated serum/plasma MCP-1 | +36.43 pg/mL (95% CI 2.43 to 70.42) | depressed subjects vs healthy controls · 8 studies of medically healthy adults with major depression | meta analysis · PMID 26903140 |