Biomarkers · Endocrine

Serum Leptin

The published study could not tell whether risk rises or falls: its 95% interval includes no change. No risk curve catalogued yet.

Published risk of death1.03×high vs low serum leptin (pooled, overall analysis) (95% CI 0.91–1.17) · Meta-analysis of 19 prospective observational studies of leptin and all-cause mortality (16 208 subjects), mixed healthy and patient populations

What studies found when this marker was changed

They describe what happened in those study groups, not a recommendation. See all catalogued interventions.

Measured changes in Serum Leptin, study by study

1 effect with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Study results in the groups studied, not predictions for a person.

Each row is one study: what was changed, the effect it reported on this marker, and the source.
Type	Intervention	Reported effect	Evidence	Source
diet	Time-restricted eating added to an exercise programme in adults, compared with a control diet plus the same exercise	Leptin 0.67 ng/mL lower (95% CI 0.33-1.02) with TRE plus exercise than exercise alone; body mass -1.86 kg, fat mass -1.52 kg	meta-analysis	Dai Z, Wan K, Miyashita M, et al. The Effect of Time-Restricted Eating Combined…

What else moves this marker

They describe those study groups, not an individual, and an association is not a cause.

Diseases and conditions

Each row is one study: what it compared and the change it reported in this marker.
What	Effect on the marker	Comparison · population	Source
↑ Ankylosing spondylitis · AS patients vs normal controls	SMD +0.829 (95% CI -0.116 to 1.774)	AS patients vs controls · 16 articles; AS patients vs normal controls (serum leptin)	meta analysis · PMID 28985620
↓ Parkinson's disease · PD patients vs healthy controls	SMD -0.4 (95% CI -2.33 to 1.53)	PD patients vs controls · 6 studies; 198 PD patients, 182 controls	meta analysis · PMID 33487251

Environmental and occupational exposures

Each row is one study: what it compared and the change it reported in this marker.
What	Effect on the marker	Comparison · population	Source
↑ Fixed night-shift work, maladapted · maladapted night-shift police officers vs permanent day-shift officers	ratio 1.22	maladapted night-shift workers vs day workers (geometric mean ratio) · 430 police officers (BCOPS study); 73 maladapted fixed-night-shift officers vs permanent day-shift officers (day-shift n not reported)	cross sectional · PMID 33781135

Sources

Kord-Varkaneh et al. Association of Serum Leptin with All-Cause and Disease Specific Mortality: A Meta-Analysis of Prospective Observational Studies. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2018;50:509-520.