PFLPhysiological Fitness Landscape

Biomarkers · Endocrine

Follicle-Stimulating Hormone (FSH)

No risk curve catalogued yet.

FSH by age and sex

Each bar runs from the 5th to the 95th percentile, the darker part from the 25th to the 75th, and the tick is the median. Not a reference range or a target.

The percentiles as a table
Each row is one sex and age band: the values below which 5%, 25%, 50%, 75% and 95% of people fall (IU/L), from the survey named in the row. Not a reference range or a target.
SexAge5th25thMedian75th95thnCycle / source
Women35-391.943.975.827.6224.7353NHANES 1999-2002
Women40-593.216.9020.256.892.61,283NHANES 1999-2002
Women6017.835.654.479.099.575NHANES 1999-2002
Womenall2.595.6912.450.389.41,711NHANES 1999-2002

What studies found when this marker was changed

They describe what happened in those study groups, not a recommendation. See all catalogued interventions.

Measured changes in FSH, study by study

3 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Study results in the groups studied, not predictions for a person.

Each row is one study: what was changed, the effect it reported on this marker, and the source.
TypeInterventionReported effectEvidenceSource
nutraceuticalSoy isoflavones, median 75 mg/day for a median of 24 weeks, in postmenopausal women (40 RCTs)No effect on FSH: MD -0.02 IU/L (95% CI -2.39 to 2.35)meta-analysisViscardi G, et al. Adv Nutr. 2025. Effect of Soy Isoflavones on Measures of…
nutraceuticalCombined black cohosh, soy isoflavone and flaxseed SDG lignan supplement daily for 90 days in postmenopausal womenFSH -6.7% difference vs placebo at 90 days (estradiol +12.6%)RCTPokushalov E, et al. Eur J Nutr. 2025. Assessing the combined effects of Black…
pharmacologicNeurokinin 3 receptor antagonist fezolinetant 180 mg/day for 12 weeks in women with PCOSAdjusted mean FSH change -1.46 IU/L (SE 0.32) vs -0.57 IU/L with placebo at 12 weeks (P = .03)RCTFraser GL, et al. J Clin Endocrinol Metab. 2021. Randomized Controlled Trial of…

Sources

  • See the catalogue entry in the research dashboard.

Related markers: Estradiol (17beta-Estradiol) · Growth Hormone (GH) · Prolactin · Serum Leptin · Thyroxine (Total T4)