Biomarkers · Inflammation
Interleukin-1 beta (IL-1b)
Lower values go with lower risk of death. No risk curve catalogued yet.
Published risk of death1.47×per 1 SD increase in IL-1beta at admission (95% CI 1.16–1.87) · Prospective cohort of 1,398 STEMI patients undergoing primary PCI; outcome all-cause mortality at 90 days (highest tertile at 1 year adjHR 1.93, 1.21-3.06)
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in IL-1b, study by study
2 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| nutraceutical | Turmeric or curcumin supplementation in adults (66 RCTs) | IL-1beta WMD -0.46 pg/mL (95% CI -1.18 to 0.27), not significant; TNF-alpha -3.48 and IL-6 -1.31 pg/mL were significant | meta-analysis | Dehzad MJ, et al. Cytokine. 2023. Antioxidant and anti-inflammatory effects of… |
| pharmacologic | Dapagliflozin 10 mg daily for 12 months in adults with type 2 diabetes without known heart failure | Plasma IL-1beta reduced by 1.8 pg/mL from baseline to 12 months (p=0.003) | RCT | Wang DD, et al. Cardiovasc Diabetol. 2024. Dapagliflozin reduces systemic… |
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ Alzheimer's disease · elderly patients with Alzheimer's disease vs controls | SMD +1.37 (95% CI 0.06 to 2.68) | Alzheimer's disease patients vs healthy controls · 1645 elderly patients with Alzheimer's disease and 14,363 controls across 34 studies | meta analysis · PMID 30104698 |
| ↑ Late-life depression · elderly patients with depression vs controls | SMD +0.642 (95% CI 0.078 to 1.206) | elderly patients with depression vs healthy controls · 2609 elderly patients with depression and 14,363 controls across 34 studies | meta analysis · PMID 30104698 |