Biomarkers · Cardiac & Hemodynamics
ST2 Soluble (sST2)
Lower values go with lower risk of death. No risk curve catalogued yet.
Published risk of death2.10×highest quartile of detectable sST2 vs undetectable sST2 (95% CI 1.40–3.20) · Dallas Heart Study, probability-based population cohort, n=3294
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in sST2, study by study
1 effect with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| pharmacologic | Atorvastatin 40 mg daily for 12 months in adults with HIV on antiretroviral therapy | Median sST2 change -0.310 ng/mL (IQR -4.195 to 2.075) with atorvastatin vs +1.163 ng/mL with placebo at 12 months | RCT | deFilippi C, Christenson R, Joyce J, et al. J Acquir Immune Defic Syndr. 2018. |
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ Acute aortic dissection · within 24 h of symptom onset, vs acute myocardial infarction | +114.5 ng/mL | acute aortic dissection (median 129.2 ng/mL) vs acute myocardial infarction (median 14.7 ng/mL) · Emergency-department patients within 24 h of symptom onset (discovery and prospective validation sets) | case control · PMID 29146682 |
| ↑ Alzheimer's disease · Alzheimer's disease patients vs healthy controls | SMD +1.23 (95% CI 0.93 to 1.53) | Alzheimer's disease patients vs healthy controls · Patients with Alzheimer's disease or mild cognitive impairment and healthy controls | meta analysis · PMID 37172376 |
| ↑ Atrial fibrillation recurring after catheter ablation · pre-ablation sST2, patients with vs without later recurrence | SMD +1.15 (95% CI 0.67 to 1.63) | AF patients with post-ablation recurrence vs those without · Patients with atrial fibrillation undergoing catheter ablation | meta analysis · PMID 38912883 |
| ↑ Pneumonia complicating inhalation injury · burn patients with inhalation injury who developed pneumonia vs those who did not | +1501 ng/mL | pneumonia (2853 ng/mL) vs no pneumonia (1352 ng/mL); summary statistic not reported · Pilot study of patients with inhalation injury | prospective cohort · PMID 33143991 |