Biomarkers · Cardiac & Hemodynamics

Cardiac (Valvular/Annular) Calcification

Lower values go with lower risk of death. No risk curve catalogued yet.

Published risk of death1.92×presence vs absence of cardiac (mitral annulus, aortic valve) calcification by… (95% CI 1.28–2.87) · 331 high-risk frail elderly subjects (mean age 86.8), PROTEGER study, France; mean follow-up 378 days

What studies found when this marker was changed

They describe what happened in those study groups, not a recommendation. See all catalogued interventions.

Each row is one study: what was changed, the effect it reported on this marker, and the source.
Type	Intervention	Reported effect	Evidence	Source
pharmacologic	Atorvastatin 80 mg daily for ~25 months in adults with calcific aortic stenosis (SALTIRE)	Ratio of post-treatment aortic-valve calcium score 0.998 (95% CI 0.947 to 1.050) vs placebo; no significant difference	RCT	Cowell SJ, Newby DE, Prescott RJ, et al. N Engl J Med. 2005.

Sources

Zhang Y, Safar ME, Iaria P, Lieber A, Peroz J, Protogerou AD, et al. Cardiac and arterial calcifications and all-cause mortality in the elderly: the PROTEGER Study. Atherosclerosis. 2010;213(2):622-6.