Biomarkers · Cardiac & Hemodynamics
QRS-T Angle
Lower values go with lower risk of death. Not measured in our NHANES panel. The curve is drawn from the published study (source below).
QRS-T Angle and risk of death
Published curve higher than the NHANES fitNHANES fit higher
Risk of death relative to the curve's reference value, drawn from the published study (source below).
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ Hypertrophic cardiomyopathy (adult, genotyped cohort) · spatial mean QRS-T angle, HCM vs healthy controls | +74.5 degrees | mean 121.8 degrees (HCM) vs 47.3 degrees (controls) · 967 genotyped HCM patients with ECG-derived VCG vs healthy controls | case control · PMID 27839835 |
| ↑ Hypertrophic cardiomyopathy (paediatric) · spatial peaks QRS-T angle, paediatric HCM vs age/sex-matched controls | +99.1 degrees | mean 120.4 degrees (HCM) vs 21.3 degrees (controls) · 130 paediatric HCM patients (14.2 y) and 470 controls with normal echocardiograms | case control · PMID 26275983 |
| ↑ Schizophrenia · frontal QRS-T angle, schizophrenia vs healthy controls | +26.11 degrees (95% CI 19.1 to 33.11) | schizophrenia vs healthy controls (frontal QRS-T angle) · 11 observational studies, 5648 patients and 23,636 controls | meta analysis · PMID 41880924 |
Genetic predisposition
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ rs7301677 (near TBX3) · per allele, standardised QRS-T angle, white participants | +0.16 SD per allele (95% CI 0.13 to 0.19) | per copy of rs7301677 effect allele (standardised beta) · ARIC and CHS: 10,769 white and 3057 black participants | gwas · PMID 29622589 |
Sources
- Risk curve: Zhang 2015 (PMID 26284799): all-cause RR 1.4 (1.32-1.48) wide vs normal spatial QRS-T angle (study-specific cut-offs), maximum-adjusted. Scaled to published population values.
- Zhang et al. Spatial/Frontal QRS-T Angle Predicts All-Cause Mortality and Cardiac Mortality: A Meta-Analysis. PloS one. 2015;10:e0136174.
Map QRS-T Angle against another biomarker.
Related markers: Abdominal Aortic Calcification (AAC) · Ankle-Brachial Index (ABI) · Cardiac (Valvular/Annular) Calcification · Carotid Intima-Media Thickness (CIMT) · Carotid-Femoral Pulse Wave Velocity (PWV) · Copeptin · Coronary Artery Calcium Score (Agatston) · Corrected QT Interval (QTc)