Biomarkers · Cardiac & Hemodynamics
Interventricular Septum Thickness
Lower values go with lower risk of death. No risk curve catalogued yet.
Published risk of death1.14×per one unit increase in IVS thickness (95% CI 1.05–1.24) · 2297 consecutive Chinese patients with angiographically verified coronary artery disease; median follow-up 25 months
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in Interventricular Septum Thickness, study by study
4 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| clinical | Catheter-based renal sympathetic denervation in patients with resistant hypertension | End-diastolic interventricular septum thickness decreased by 0.78 mm (95% CI 0.49-1.06) after renal denervation | meta-analysis | Xie L, Li Y, Luo S, et al. Impact of renal denervation on cardiac remodeling in… |
| clinical | Radiofrequency catheter septal ablation in patients with hypertrophic obstructive cardiomyopathy | IVS thickness reduced by 3.61 mm (95% CI 1.59-5.64) after radiofrequency septal ablation | meta-analysis | da Silva Menezes A, Sanches MR, de Oliveira Filho E, et al. Radiofrequency… |
| pharmacologic | Nitrendipine 2x5 mg (normotensive) or 2x10-20 mg daily (hypertensive) for at least 12 months after renal transplantation | Septal wall thickness -0.83 +/- 2.23 mm on nitrendipine vs +0.97 +/- 2.20 mm on placebo (between-group P=0.048) | RCT | Rockstroh JK, Schobel HP, Vogt-Ladner G, et al. Blood pressure independent… |
Things that worsen it
| Type | Condition or exposure | Reported effect | Evidence | Source |
|---|---|---|---|---|
| pharmacologic | Recombinant growth hormone treatment in adults with growth hormone deficiency | IVS thickness increased by 0.28 mm (SD 0.38) with GH treatment (P<0.001) | meta-analysis | Maison P, Chanson P. Cardiac effects of growth hormone in adults with growth… |
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ Metabolic syndrome in hypertension (comparable blood pressure) · hypertensive patients with metabolic syndrome vs hypertension alone at comparable blood pressure | +0.49 mm (95% CI 0.28 to 0.71) | hypertension plus metabolic syndrome vs hypertension alone · Hypertensive adults with and without metabolic syndrome (4 of 14 cross-sectional studies with comparable blood pressure) | meta analysis · PMID 23371816 |
| ↑ Rheumatoid arthritis · RA patients without cardiovascular disease vs controls | SMD +0.39 (95% CI 0.07 to 0.71) | RA patients vs control subjects · Patients with rheumatoid arthritis asymptomatic for cardiovascular disease and controls (16 case-control studies) | meta analysis · PMID 25753937 |
| ↓ Sleep apnea comorbid with hypertrophic cardiomyopathy · HCM patients with sleep apnea vs HCM patients without sleep apnea | -1.25 mm (95% CI -2.44 to -0.06) | HCM with sleep apnea vs HCM without sleep apnea · Patients with hypertrophic cardiomyopathy, with and without sleep apnea (8 studies) | meta analysis · PMID 42260027 |
Genetic predisposition
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↑ ACE insertion/deletion D/D genotype in hypertrophic cardiomyopathy · progression of septal thickness over follow-up, D/D vs I/D genotype | +4.5 mm | increase of 6.2 mm (D/D) vs 1.7 mm (I/D) over a mean 6.0 years of follow-up · Patients with hypertrophic cardiomyopathy followed with serial echocardiography for at least 2 years | prospective cohort · PMID 15314809 |
| ↑ NPPA promoter -A2843G (GG genotype), hypertension with LVH · GG vs AA or AG genotype in hypertensive patients with left ventricular hypertrophy | +0.9 mm | septal wall thickness 11.8 mm (GG) vs 10.9 mm (AA) and 10.7 mm (AG) · Chinese hypertensive patients with LVH (n=945), without LVH (n=1173) and healthy controls (n=816) | case control · PMID 17672826 |