Biomarkers · Vitamins & Endocrine

Estradiol-to-SHBG Ratio

No risk curve catalogued yet.

What studies found when this marker was changed

They describe what happened in those study groups, not a recommendation. See all catalogued interventions.

Measured changes in Estradiol-to-SHBG Ratio, study by study

2 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Study results in the groups studied, not predictions for a person.

Each row is one study: what was changed, the effect it reported on this marker, and the source.
Type	Intervention	Reported effect	Evidence	Source
lifestyle	5 ounces of white wine daily for 3 weeks (vs 6 oz white grape juice) in postmenopausal ER+ breast cancer survivors taking aromatase inhibitors	Free estradiol index changed by -0.7% (95% CI -2% to 0.7%) with daily wine vs grape juice over 3 weeks (not significant)	RCT	Mostofsky E, et al. Breast Cancer Res. 2025. Effect of daily alcohol intake on…

Things that worsen it

Each row is one study: what was changed, the effect it reported on this marker, and the source.
Type	Condition or exposure	Reported effect	Evidence	Source
diet	Calorie-restricted diet targeting ~10% weight loss by 6 months then maintenance to 12 months in frail, obese men aged >=65	Free estradiol index fell by 0.39 pmol/nmol (diet) and 0.52 pmol/nmol (diet+exercise) from baseline at 12 months, with weight loss of 10.1 kg and 9.1 kg	RCT	Armamento-Villareal R, et al. J Nutr Health Aging. 2016. Effect of Lifestyle…

What else moves this marker

They describe those study groups, not an individual, and an association is not a cause.

Genetic predisposition

Each row is one study: what it compared and the change it reported in this marker.
What	Effect on the marker	Comparison · population	Source
↑ CYP19 (aromatase) intron 4 TTTA repeat, A2 allele ([TTTA]7) · A2 allele carriers vs non-carriers; free estradiol index	ratio 1.106	A2 allele present (0.52) vs absent (0.47), free estradiol index · Women aged >=70 years, Western Australia; A2 allele present in 27%	cross sectional · PMID 15613678

Sources

See the catalogue entry in the research dashboard.