Biomarkers · Vitamins & Endocrine
Adiponectin
Lower values go with lower risk of death. Not measured in our NHANES panel. The curve is drawn from the published study (source below).
Adiponectin and risk of death
Published curve higher than the NHANES fitNHANES fit higher
Risk of death relative to the curve's reference value, drawn from the published study (source below).
Adiponectin by age and sex
The percentiles as a table
| Sex | Age | 5th | 25th | Median | 75th | 95th | n | Cycle / source |
|---|---|---|---|---|---|---|---|---|
| Men | all | – | 7.00 | 9.00 | 12.2 | – | 1,080 | Framingham Offspring c… |
| Women | all | – | 10.7 | 14.8 | 20.5 | – | 1,012 | Framingham Offspring c… |
What studies found when this marker was changed
They describe what happened in those study groups, not a recommendation. See all catalogued interventions.
Measured changes in Adiponectin, study by study
3 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Green points move the marker the way lower risk of death lies; amber the other way. Study results in the groups studied, not predictions for a person.
| Type | Intervention | Reported effect | Evidence | Source |
|---|---|---|---|---|
| diet | MIND or control diet with mild caloric restriction (-250 kcal/day) for 3 years in overweight adults aged 65-84; effect shown for the >10% weight-loss category | Adiponectin increased by 53.7% at year 3 in participants losing >10% body weight vs those with no weight loss | cohort | Dhana K, et al. International journal of obesity (2005). 2025. Effect of weight… |
| pharmacologic | Enavogliflozin (selective SGLT2 inhibitor) daily for 24 weeks in adults with type 2 diabetes (phase III, secondary analysis) | Raises serum adiponectin by 0.98 ug/mL (LS mean difference vs placebo) at 24 weeks | RCT | Lyu YS, et al. Cardiovascular diabetology. 2025. Weight-independent… |
Things that worsen it
| Type | Condition or exposure | Reported effect | Evidence | Source |
|---|---|---|---|---|
| diet | Three weeks of 50% caloric restriction in nonobese men (Minnesota Starvation Experiment revisited; preceded by 1 week overfeeding) | Plasma adiponectin fell by 49% after 3 weeks of 50% caloric restriction | non-randomised trial | Müller MJ, et al. The American journal of clinical nutrition. 2015. Metabolic… |
What else moves this marker
They describe those study groups, not an individual, and an association is not a cause.
Diseases and conditions
| What | Effect on the marker | Comparison · population | Source |
|---|---|---|---|
| ↕ Bipolar disorder · BD patients vs healthy controls (pooled Hedges g) | SMD +0.28 (95% CI -0.34 to 0.9) | BD patients vs healthy controls · Adults with bipolar disorder (11 studies; 477 patients, 380 controls) | meta analysis · PMID 30818254 |
Sources
- Risk curve: Scarale MG 2018 (PMID 30388239): all-cause HR 1.24 (1.17-1.31) per 1 SD increment of adiponectin (pooled). Scaled to published population values.
- Scarale MG, Fontana A, Trischitta V, Copetti M, Menzaghi C. Circulating adiponectin levels are paradoxically associated with mortality rate. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2018.
Map Adiponectin against another biomarker.
Related markers: C-peptide · Dehydroepiandrosterone Sulfate (DHEA-S) · Estradiol-to-SHBG Ratio · Free Triiodothyronine (Free T3) · Insulin-like Growth Factor 1 (IGF-1) · Serum 25-Hydroxyvitamin D · Serum Cortisol · Serum Folate