PFLPhysiological Fitness Landscape

Biomarkers · Urine Biomarkers

Urine Specific Gravity

No risk curve catalogued yet.

Urine Specific Gravity by age and sex

Each bar runs from the 5th to the 95th percentile, the darker part from the 25th to the 75th, and the tick is the median. Not a reference range or a target.

The percentiles as a table
Each row is one sex and age band: the values below which 5%, 25%, 50%, 75% and 95% of people fall (ratio), from the survey named in the row. Not a reference range or a target.
SexAge5th25thMedian75th95thnCycle / source
All20-391.011.011.021.021.031,409NHANES 2007-2008
All40-591.001.011.021.021.031,527NHANES 2007-2008
All60+1.001.011.011.021.021,659NHANES 2007-2008
Allall1.001.011.021.021.034,595NHANES 2007-2008
Men20-391.011.011.021.021.03718NHANES 2007-2008
Men40-591.011.011.021.021.03742NHANES 2007-2008
Men60+1.011.011.021.021.03839NHANES 2007-2008
Menall1.011.011.021.021.032,299NHANES 2007-2008
Women20-391.001.011.021.021.03691NHANES 2007-2008
Women40-591.001.011.011.021.03785NHANES 2007-2008
Women60+1.001.011.011.021.02820NHANES 2007-2008
Womenall1.001.011.011.021.032,296NHANES 2007-2008

What studies found when this marker was changed

They describe what happened in those study groups, not a recommendation. See all catalogued interventions.

Measured changes in Urine Specific Gravity, study by study

4 effects with a numeric size, each from one study arm: the dot is the reported change, the line its 95% interval where one was given. Study results in the groups studied, not predictions for a person.

Each row is one study: what was changed, the effect it reported on this marker, and the source.
TypeInterventionReported effectEvidenceSource
dietConsistent daily fluid hydration (2.5-3.5 L/day water intake)High drinkers (2–4 litres/d) had 24h urine specific gravity median 1·010 vs 1·023 in low drinkers (≤ 1·2 litres/d)cross-sectionalPerrier E, et al. Hydration biomarkers in free-living adults with different…
exerciseFluid replacement (150% of sweat losses) after heavy endurance exerciseReplacing 150% vs 75% of sweat losses after a run lowered next-morning USG (1.014 vs 1.026)non-randomised trialDavis BA, et al. Hydration kinetics and 10-km outdoor running performance…
lifestyleStructured hydration education increasing daily water intakeRaised daily water intake (749.8 vs 572.9 mL) and improved urine specific gravity vs control (p < .001)RCTÇimen A, et al. Health Belief Model-Based Education to Improve Water Intake and…
lifestyleConsuming the recommended 2.5 L of fluid per 24 h (euhydration day) versus usual ad libitum intake in healthy young womenUSG went from 1.014 at baseline to 1.010 by 5 PM on the euhydration day (vs 1.011 on the control day and 1.021 on the dehydration day; P<0.05)RCTStachenfeld NS, et al. Physiol Behav. 2018. Water intake reverses dehydration…
pharmacologicTolvaptan (vasopressin V2 antagonist) titrated by body weight and tolerability in children and adolescents aged 4-17 with autosomal dominant polycystic kidney diseaseSpot urine specific gravity fell by 0.009 (LS mean, SEM 0.001) at week 1 vs 0.002 with placebo (P<0.001)RCTMekahli D, et al. Clin J Am Soc Nephrol. 2023. Tolvaptan for Children and…

Things that worsen it

Each row is one study: what was changed, the effect it reported on this marker, and the source.
TypeCondition or exposureReported effectEvidenceSource
clinicalAdvanced chronic kidney disease / isosthenuriaFailing kidney gradually develops hyposthenuria and even isosthenuria (fixed urine concentration; effect size not reported)reviewKovesdy CP. Significance of hypo- and hypernatremia in chronic kidney disease…
environmentalHeat-induced dehydration (passive heat exposure with body water loss)5-h heat exposure (36 °C) with 1-2% body mass loss significantly increased USG vs baseline (effect size not reported)RCTMuñoz CX, et al. Assessment of hydration biomarkers including salivary…
lifestyleMinimising fluid intake over a day of normal activity in healthy young women (dehydration session)USG rose from 1.015 at baseline to 1.021 by 5 PM on the dehydration day (vs 1.011 on the control day; P<0.05)RCTStachenfeld NS, et al. Physiol Behav. 2018. Water intake reverses dehydration…

Sources

  • See the catalogue entry in the research dashboard.

Related markers: Proteinuria (Dipstick) · Urinary Creatinine Concentration · Urinary Flow Rate · Urine Albumin-to-Creatinine Ratio (uACR)